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arXiv:1910.14538 · Nature Communications

Matter-wave interference of a native polypeptide

A. Shayeghi, P. Rieser, G. Richter, U. Sezer, J. H. Rodewald, P. Geyer, Todd J. Martı́nez, Markus Arndt

Published Mar 19, 2020• 57 citations
arXivHTMLPDF

Abstract

The de Broglie wave nature of matter is a paradigmatic example of quantum physics and it has been exploited in precision measurements of forces and fundamental constants. However, matter-wave interferometry has remained an outstanding challenge for natural polypeptides, building blocks of life, which are fragile and difficult to handle. Here, we demonstrate the wave nature of gramicidin, a natural antibiotic composed of 15 amino acids. Its center of mass is delocalized over more than 20 times the molecular size in our time-domain Talbot-Lau interferometer. We compare the observed interference fringes with a model that includes both a rigorous treatment of the peptide's quantum wave nature as well as a quantum chemical assessment of its optical properties to distinguish our result from classical predictions. The realization of quantum optics with this prototypical biomolecule paves the way for quantum-assisted measurements on a large class of biologically relevant molecules.

DOI
10.1038/s41467-020-15280-2

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The de Broglie wave nature of matter is a paradigmatic example of quantum physics and it has been exploited in precision measurements of forces and fundamental constants. However, matter-wave interferometry has remained an outstanding challenge for natural polypeptides, building blocks of life, which are fragile and difficult to handle. Here, we demonstrate the wave nature of gramicidin, a natural antibiotic composed of 15 amino acids. Its center of mass is delocalized over more than 20 times the molecular size in our time-domain Talbot-Lau interferometer. We compare the observed interference fringes with a model that includes both a rigorous treatment of the peptide's quantum wave nature as well as a quantum chemical assessment of its optical properties to distinguish our result from classical predictions. The realization of quantum optics with this prototypical biomolecule paves the way for quantum-assisted measurements on a large class of biologically relevant molecules.
Abstract The de Broglie wave nature of matter is a paradigmatic example of quantum physics and it has been exploited in precision measurements of forces and fundamental constants. However, matter-wave interferometry has remained an outstanding challenge for natural polypeptides, building blocks of life, which are fragile and difficult to handle. Here, we demonstrate the wave nature of gramicidin, a natural antibiotic composed of 15 amino acids. Its center of mass is delocalized over more than 20 times the molecular size in our time-domain Talbot-Lau interferometer. We compare the observed interference fringes with a model that includes both a rigorous treatment of the peptide’s quantum wave nature as well as a quantum chemical assessment of its optical properties to distinguish our result from classical predictions. The realization of quantum optics with this prototypical biomolecule paves the way for quantum-assisted measurements on a large class of biologically relevant molecules.
Modern quantum optics encompasses a wide field of phenomena that are either related to the discrete quantum nature of light, the quantum wave nature of matter or light-matter interactions.We here discuss new perspectives for quantum optics with biological nanoparticles.We focus in particular on the prospects of matter-wave interferometry with amino acids, nucleotides, polypeptides or DNA strands.We motivate the challenge of preparing these objects in a 'biomimetic' environment and argue that hydrated molecular beam sources are promising tools for quantum-assisted metrology.The method exploits the high sensitivity of matter-wave interference fringes to dephasing and shifts in the presence of external perturbations to access and determine molecular properties.
These lecture notes emerged from a contribution to the "Les Houches Summer School, Session CVII - Current Trends in Atomic Physics, July 2016". It is meant to serve students as a guide to a selection of topics that are currently at the focus of molecular quantum optics and complements an earlier lecture on related topics [Arndt et al., 2014]. In this review we discuss recent advances in molecular quantum optics with large organic molecules. In particular, we present successful experiments of molecules of biological importance, such as neurotransmitters and map out the route towards interferometry of large bio-matter such as proteins. The interaction of internally complex molecules with various beam splitters is discussed for both far-field diffraction at a single nanomechanical grating and the Kapitza-Dirac Talbot-Lau near-field interferometer - addressing recent progress, experimental challenges, and prospects for quantum enhanced metrology of highly complex systems in the gas phase. A central part of this review deals with the preparation of slow beams of neutral biomolecules, ranging from a single amino acid to proteins or peptides in a micro-environment.
The chapter discusses advances in matter-wave optics with complex molecules, generalizing Young’s double slit to high masses. The quantum wave-particle duality is visualized by monitoring the arrival patterns of molecules diffracted at nanomechanical masks. Each molecule displays particle behavior when it is localized on the detector; however, the overall interference pattern requires their delocalization in free flight. Internal particle properties influence the de Broglie waves in the presence of surfaces or fields—even in interaction with atomically thin gratings. To probe the quantum nature of high-mass molecules, universal beam splitters are combined in a multi-grating interferometer to observe high-contrast matter-wave fringes even for 500 K hot molecules, containing 810 atoms with a mass of 10 000 amu. The high sensitivity of the nanoscale interference fringes to deflection in external fields enables non-invasive measurements of molecular properties. The chapter concludes by discussing research on beam techniques that extend molecular quantum optics to large biomolecules.
The wave nature of matter is a key ingredient of quantum physics and yet it defies our classical intuition. First proposed by Louis de Broglie a century ago, it has since been confirmed with a variety of particles from electrons up to molecules. Here we demonstrate new high-contrast quantum experiments with large and massive tailor-made organic molecules in a near-field interferometer. Our experiments prove the quantum wave nature and delocalization of compounds composed of up to 430 atoms, with a maximal size of up to 60 Å, masses up to m=6,910 AMU and de Broglie wavelengths down to λdB=h/mv≃1 pm. We show that even complex systems, with more than 1,000 internal degrees of freedom, can be prepared in quantum states that are sufficiently well isolated from their environment to avoid decoherence and to show almost perfect coherence. Observing superposition states of mesoscopic quantum systems is an ongoing challenge. Gerlichet al. report quantum interference of large tailor-made organic compounds, demonstrating delocalization and the quantum wave nature of entire molecules composed of up to 430 atoms.
We discuss new de Broglie coherence experiments in a near-field molecule interferometer with a variety of large organic molecules. While de Broglie coherence is to first order only associated with the center-of-mass motion of the diffracted particle, we here investigate the question as to which extent the internal molecular property is relevant for, compatible with or detrimental for maintaining coherence in the translational degree of freedom. External perturbations, such as inhomogeneous external electric fields, may influence the delocalized molecules inside the matter wave interferometer and they allow us to access the molecular polarizabilities, permanent or even fluctuating electric dipole moments. We extract information about the molecular states from the interference phase shifts as well as from the observed dephasing in a Kapitza-Dirac Talbot-Lau-Stark-deflectometer. We discuss the relevance of our experiments with regard to both molecule metrology and the foundations of quantum mechanics, i.e. the preservation of coherence for highly complex particles in external fields.